Toxicity of pindone

From page 31, NRA report from National Registration Authority for Agricultural and Veterinary Chemicals, Australia

3.3.1.11

Summary of primary toxicity testing

Subacute sensitivities of a variety of animals to pindone have been tabulated by Twigg et al(1999) as reproduced below. The studies do not allow determination of an LD50 because only a single dosing level was used.

Data indicate that rabbits are generally more sensitive than other vertebrates to pindone. However, it is not possible to conclude with any degree of certainty that rabbits are the most sensitive animal in the table below, given the unique aspects of toxicity testing with anticoagulants as outlined earlier in this report. Some raptors appear to share the high sensitivity of rabbits, based on results for wedge-tailed eagles and brown goshawks. Kangaroos also appear highly sensitive, based on results for western greys. Some of the animals in the table (cattle, cats, bush rats, wedge-tailed eagles, bronzewings and Port Lincoln parrots) that survived exposure were nevertheless considered possible casualties of pindone baiting operations as they exhibited clinical symptoms or prothrombin inhibition.

Advice from the APB of WA is that no toxicity testing has been conducted with bandicoots, but oat consumption has been investigated, with or without alternative food. Results indicated that southern brown bandicoots consuming 0.025% pindone oat baits could ingest up to 2mg/kg/day pindone, but actual field exposures are difficult to predict as laboratory-based feeding trials suggest that bandicoots are likely to de-husk oat bait